Detection of dengue virus serotype 3 in Cajamarca, Peru: Molecular diagnosis and clinical characteristics
نویسندگان
چکیده
Objective: To describe and molecularly characterize an outbreak of dengue virus (DENV) infection in Cajamarca, Andean region Peru.Methods: A total 359 serum samples from patients with acute febrile illness were assessed for the presence DENV via RT-PCR, ELISA NS1, IgM IgG Peru January 2017 to June 2017. The evaluation different diagnostic tests their applicability was performed.Results: Dengue detected 24.7% by RT-PCR. Meanwhile, serological analysis 30.3% positive cases NS1 antigen, 16.7% 9.7% IgM. Most corresponded DENV-3 (77.5%). use RT-PCR performed better primary infections (P<0.01), while detection secondary (P<0.01). combination than other assays detecting (92.5%) (96.6%). most frequent symptoms associated fever headaches, myalgias, arthralgias across all groups.Conclusions: We report important caused Peru. Our findings encourage antigen co-detection. These demonstrate increasing expansion highlight importance molecular diagnosis serotype characterization among clinically defined strengthen Peruvian epidemiological surveillance.
منابع مشابه
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In 2008, dengue virus serotype 4 (DENV-4) emerged in northeastern Peru, causing a large outbreak and displacing DENV-3, which had predominated for the previous 6 years. Phylogenetic analysis of 2008 and 2009 isolates support their inclusion into DENV-4 genotype II, forming a lineage distinct from strains that had previously circulated in the region.
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ژورنال
عنوان ژورنال: Asian Pacific Journal of Tropical Medicine
سال: 2021
ISSN: ['1995-7645']
DOI: https://doi.org/10.4103/1995-7645.326257